This article offers a perverse reason why people gain weight and then can’t lose it. It’s because there are calories in fat cells that are NOT in the bloodstream…so your body tells you you’re hungry, your metabolism slows down, and you feel the compulsion to eat.

As it turns out, many biological factors affect the storage of calories in fat cells, including genetics, levels of physical activity, sleep and stress. But one has an indisputably dominant role: the hormone insulin. We know that excess insulin treatment for diabetes causes weight gain, and insulin deficiency causes weight loss. And of everything we eat, highly refined and rapidly digestible carbohydrates produce the most insulin.

Like an infection that raises the body temperature set point, high consumption of refined carbohydrates—chips, crackers, cakes, soft drinks, sugary breakfast cereals and even white rice and bread—has increased body weights throughout the population.

People in the modern food environment seem to have greater control over what they eat than how much. With reduced consumption of refined grains, concentrated sugar and potato products and a few other sensible lifestyle choices, our internal body weight control system should be able to do the rest.